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Showing 1–5 of 5 results
Advanced filters: Author: Owen J Tamplin Clear advanced filters
  • The endocardium lines the interior of the heart chambers and has been debated as a source of hematopoietic lineages. Here they show that the endocardium may act as a source of, and resident tissue for, hematopoietic stem and progenitor cells in zebrafish, providing evidence for diversity in origins and residences of hematopoietic cells.

    • Dorothee Bornhorst
    • Amulya V. Hejjaji
    • Felix Gunawan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • A platform for automated screening of zebrafish larvae in high throughput should allow detection of phenotypic changes in single cells.

    • Owen J Tamplin
    • Leonard I Zon
    News & Views
    Nature Methods
    Volume: 7, P: 600-601
  • It is unclear whether arterial specification is required for hematopoietic stem cell formation. Here, the authors use a chemically defined human pluripotent stem cell (hPSC) differentiation system to show the role of NOTCH signaling in forming arterial-type hemogenic endothelial cells.

    • Gene I. Uenishi
    • Ho Sun Jung
    • Igor I. Slukvin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14
  • An in vivo imaging-based competitive transplant screen in zebrafish identifies epoxyeicosatrienoic acids as enhancers of haematopoietic stem and progenitor cell (HSPC) engraftment; these derivatives of arachidonic acid also promote zebrafish developmental HSPC specification through a PI(3)K-dependent AP-1 and runx1 transcriptional program and their pro-engraftment effect is conserved in mammals (indicating clinical potential).

    • Pulin Li
    • Jamie L. Lahvic
    • Leonard I. Zon
    Research
    Nature
    Volume: 523, P: 468-471