Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–10 of 10 results
Advanced filters: Author: Pál Pacher Clear advanced filters

  • Here, Haskó and colleagues discuss how an increased awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.

    • György Haskó
    • Joel Linden
    • Pál Pacher
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 759-770

  • Over the past decade, marijuana has been legalized for medicinal purposes or recreational use in many countries, and the potency of marijuana and synthetic cannabinoids has substantially increased. In this Review, Pacher and colleagues summarize the role of the endocannabinoid system in cardiovascular health and disease, and critically discuss the beneficial and detrimental cardiovascular effects of marijuana and synthetic cannabinoid use.

    • Pal Pacher
    • Sabine Steffens
    • George Kunos
    Reviews
    Nature Reviews Cardiology
    Volume: 15, P: 151-166

  • The adenosine–adenosine receptor system has a key role in regulating glucose homeostasis and in the pathophysiology of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). In this Review, the authors discuss the role of the adenosinergic system in regulating both the onset and progression of T1DM and T2DM, and the potential of manipulating this system as an approach to manage T1DM, T2DM and their associated complications.

    • Luca Antonioli
    • Corrado Blandizzi
    • György Haskó
    Reviews
    Nature Reviews Endocrinology
    Volume: 11, P: 228-241

  • Cannabinoids inhibit motility and secretion in the intestine. They are now assigned the additional task of curbing excessive inflammation, suggesting that drugs targeting the endogenous cannabinoid system could be exploited for inflammatory bowel disease.

    • George Kunos
    • Pál Pacher
    News & Views
    Nature Medicine
    Volume: 10, P: 678-679

  • Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.

    • Luca Antonioli
    • Corrado Blandizzi
    • György Haskó
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 18, P: 537-538

  • Several studies have recently highlighted a crucial role for adenosine signalling in regulating various aspects of the cell-intrinsic and cell-extrinsic processes of cancer development. This Review critically discusses adenosine and its effects on immune, endothelial and cancer cells during the course of neoplastic disease.

    • Luca Antonioli
    • Corrado Blandizzi
    • György Haskó
    Reviews
    Nature Reviews Cancer
    Volume: 13, P: 842-857

  • Evgenovet al. review the discovery, biochemistry and pharmacology of nitric oxide-independent stimulators and activators of soluble guanylate cyclase, a key signal-transduction enzyme, and discuss their potential for treating arterial and pulmonary hypertension, heart failure, atherosclerosis, thrombosis, erectile dysfunction, renal fibrosis and failure, and liver cirrhosis.

    • Oleg V. Evgenov
    • Pál Pacher
    • Johannes-Peter Stasch
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 755-768