The X-ray crystal structure of human leukotriene C4 synthase, in its apo- and glutathione -complexed forms at 2.00 and 2.15 Å resolution, respectively, is solved. The structure of the enzyme in complex with substrate reveals that the active site enforces a horseshoe-shaped conformation of glutathione and positions its thiol group in a way that explains the selectivity of its chemical reaction.
- Daniel Martinez Molina
- Anders Wetterholm
- Pär Nordlund
