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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

The naturally occurring compound urolithin A has been found to promote mitophagy, thereby increasing lifespan in worms and improving skeletal muscle activity in rodents.

Dongryeol Ryu
Laurent Mouchiroud
Johan Auwerx
Research11 Jul 2016
Nature Medicine

Volume: 22, P: 879-888
Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Pénélope A. Andreux
Marcus P. J. van Diemen
Anurag Singh
Amendments and CorrectionsOpen Access25 Nov 2019
Scientific Reports

Volume: 9, P: 1
Pharmacological approaches to restore mitochondrial function

Dysfunctional mitochondria are implicated in rare, inherited mitochondrial diseases as well as a variety of common age-related disorders. Here, Auwerx and colleagues provide an overview of diseases that affect mitochondria, highlight strategies for therapeutically intervening in mitochondrial pathways and discuss screening strategies for drug identification.

Pénélope A. Andreux
Riekelt H. Houtkooper
Johan Auwerx
Reviews13 May 2013
Nature Reviews Drug Discovery

Volume: 12, P: 465-483
Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Pénélope A. Andreux
Marcus P. J. van Diemen
Anurag Singh
ResearchOpen Access04 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Here the authors report the results of a first-in-human trial with urolithin A in healthy elderly individuals, demonstrating that the compound is well tolerated and bioavailable after oral administration. They also provide clinical data indicating that urolithin A may improve mitochondrial and cellular health in human muscle.

Pénélope A. Andreux
William Blanco-Bose
Chris Rinsch
Research14 Jun 2019
Nature Metabolism

Volume: 1, P: 595-603
Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

Anurag Singh
Davide D’Amico
Chris Rinsch
ResearchOpen Access11 Jun 2021
European Journal of Clinical Nutrition

Volume: 76, P: 297-308
A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

Pénélope A. Andreux
Laurent Mouchiroud
Johan Auwerx
ResearchOpen Access13 Jun 2014
Scientific Reports

Volume: 4, P: 1-10
The metabolic footprint of aging in mice

Riekelt H. Houtkooper
Carmen Argmann
Johan Auwerx
ResearchOpen Access31 Oct 2011
Scientific Reports

Volume: 1, P: 1-11

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

Pharmacological approaches to restore mitochondrial function

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

The metabolic footprint of aging in mice

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