As our understanding of the molecular and biochemical events that underlie the development of systemic sclerosis advances, so does our ability to develop novel targeted therapies for this complex, autoimmune, connective-tissue disease. In this Review, Christopher Denton and colleagues provide an overview of the pathogenesis of systemic sclerosis and discuss the current treatment approaches for managing organ-based complications of this disease.
- Christopher P Denton
- Carol M Black
- David J Abraham
