This Review outlines the individual genes that have been described in familial combined hyperlipidaemia (FCHL) and how these genes can be incorporated into the current concept of metabolic pathways resulting in FCHL: adipose tissue dysfunction, hepatic fat accumulation and overproduction, disturbed metabolism and delayed clearance of apolipoprotein B-containing particles.
- Martijn C. G. J. Brouwers
- Marleen M. J. van Greevenbroek
- Anton F. H. Stalenhoef
