Two independent crystal structure analyses have resolved the detailed interactions between botulinum neurotoxin serotype B and its neuronal receptor, synaptotagmin. The studies show how the toxin binds synaptotagmin and, along with previously determined interactions with the ganglioside GT1b, a coreceptor, explain the toxin's extreme toxicity and tropism for neurons.
- Michael R Baldwin
- Jung-Ja P Kim
- Joseph T Barbieri
