Toxin proteins can cause physical damage, biochemical degradation and signaling interruption in mammals, leading to disabilities and even death. Most of the current antitoxins are developed against specific toxins. The broad-spectrum antitoxic platforms are still rare. Here, we developed a reactive conjugated polymer, PPV-NHS, which selectively reacted with basic proteins and reduced the activity of these attached proteins. PPV-NHS showed excellent inhibition effect on neurotoxicity and hemolysis caused by α-bungarotoxin and cardiotoxin in vitro and in vivo. This work represents the rational design of functionalized conjugated polymers for anti-virulence therapy with both high efficiency and broad applicability.
