Nature Search

Natural killer cells’ functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

Juan Jose Rodriguez-Sevilla
Irene Ganan-Gomez
Simona Colla
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Single-cell multi-omics analysis of the immune response in COVID-19

Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

Emily Stephenson
Gary Reynolds
Muzlifah Haniffa
ResearchOpen Access20 Apr 2021
Nature Medicine

Volume: 27, P: 904-916
Venous-plexus-associated lymphoid hubs support meningeal humoral immunity

Dural-associated lymphoid tissues are lymphoid structures around vascular hubs in the dura mater that sample antigens and rapidly support humoral immune responses after local pathogen challenge.

Zachary Fitzpatrick
Nagela Ghabdan Zanluqui
Dorian B. McGavern
Research20 Mar 2024
Nature

Volume: 628, P: 612-619
Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

There are no reliable tests for placental insufficiency, which can lead to fetal growth restriction and stillbirth. Here the authors demonstrate that low levels of circulating SPINT1 are associated to low birthweight, and several ultrasound and neonatal anthropomorphic indicators of placental insufficiency.

Tu’uhevaha J. Kaitu’u-Lino
Teresa M. MacDonald
Stephen Tong
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-10
Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells

The dysfunction of IL-10 secreting regulatory B cells has been linked to the pathogenesis of autoimmune disease. Here the authors show that low dose IL-2 therapy can enhance IL-10 production in regulatory B cell populations via the modulation of BACH2.

Akimichi Inaba
Zewen Kelvin Tuong
Menna R. Clatworthy
ResearchOpen Access12 Apr 2023
Nature Communications

Volume: 14, P: 1-11
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

Endogenous formaldehyde accumulation reveals Cockayne syndrome in mice and stimulates production of the anorexiogenic peptide GDF15 in proximal tubule cells.

Lee Mulderrig
Juan I. Garaycoechea
Ketan J. Patel
Research24 Nov 2021
Nature

Volume: 600, P: 158-163
MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides

Defective immune responses have been reported in cutaneous T-cell lymphoma (CTCL). Here the authors show that in patients with mycosis fungoides, the most common CTCL, malignant T cells upregulate MHC-I as a mechanism to evade NK-mediated immunity.

Yun-Tsan Chang
Pacôme Prompsy
Emmanuella Guenova
ResearchOpen Access25 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage

Zewen K. Tuong
Andrew Lewandowski
James W. Wells
ResearchOpen Access28 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
Two decades of rice research in Indonesia and the Philippines: A systematic review and research agenda for the social sciences

Ginbert P. Cuaton
Laurence L. Delina
ReviewsOpen Access14 Oct 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-21
Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses

Hwee-Ing Ng
Zewen K. Tuong
Mark A. F. Kendall
ResearchOpen Access11 Oct 2019
npj Vaccines

Volume: 4, P: 1-12
Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Damanpreet Garcha
Susan P. Walker
Tu’uhevaha J. Kaitu’u-Lino
ResearchOpen Access16 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham
Teresa M. MacDonald
Tu’uhevaha J. Kaitu’u-Lino
ResearchOpen Access18 Jan 2019
Scientific Reports

Volume: 9, P: 1-12
MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Carole-Anne Whigham
Teresa M. MacDonald
Tu’uhevaha J. Kaitu’u-Lino
ResearchOpen Access22 Oct 2020
Scientific Reports

Volume: 10, P: 1-11
Mammographic texture features associated with contralateral breast cancer in the WECARE Study

Gordon P. Watt
Julia A. Knight
Jonine L. Bernstein
ResearchOpen Access29 Nov 2021
npj Breast Cancer

Volume: 7, P: 1-4
Body mass index (BMI) dynamics in vietnam

N T Tuan
P D Tuong
B M Popkin
Research14 Feb 2007
European Journal of Clinical Nutrition

Volume: 62, P: 78-86

Search

Filter By:

Search

Quick links