Adipocytes store energy and regulate themselves depending on the environment. Clinical studies suggest that excess macronutrient intake may induce cellular lipid loading and promote signs of inflammatory stress, which ultimately leads to metabolic dysfunction. This Review discusses how lipid mediators may act on important immune receptors to induce low-grade tissue inflammation, which leads to adipocyte and metabolic dysfunction in obesity.
- Abishek Iyer
- David P. Fairlie
- Lindsay Brown
