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Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development

The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the early placenta, enabling investigation of placenta development and evaluation of therapeutics for placenta dysfunction disorders.

Claire Richards
Hao Chen
Lana McClements
ResearchOpen Access12 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

TANK-binding kinase-1 (TBK1) and its homologue IκB kinase-ε (IKKε) are critical in the induction of the interferon response and the response to infection by pathogens. Here the authors show that pharmacological targeting of TBK1 AND IKKε reduces the immunopathology seen in a murine model of SARS-COV-2 infection.

Tomalika R. Ullah
Matt D. Johansen
Michael P. Gantier
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Neutron diffraction reveals the orientation of the headgroup of inositol lipids in model membranes

Neutron diffraction studies show that the inositol ring in the headgroup of phosphatidylinositol extends perpendicular to the membrane surface but that phosphorylation of the 4-position causes the ring to tilt over.

Jeremy P. Bradshaw
Richard J. Bushby
David G. Reid
Correspondence01 Feb 1996
Nature Structural Biology

Volume: 3, P: 125-127
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice

Current vaccines against SARS-CoV-2 reduce mortality but are less effective in preventing infection. Here the authors show that intranasal vaccination with a subunit vaccine including an TLR2-stimulating adjuvant induces strong neutralising antibody and T-cell responses against SARS-CoV-2 in the lungs that protect against infection.

Anneliese S. Ashhurst
Matt D. Johansen
Warwick J. Britton
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-18
A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

Claudio Counoupas
Matt D. Johansen
James A. Triccas
ResearchOpen Access30 Nov 2021
npj Vaccines

Volume: 6, P: 1-10
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Group 2 innate lymphoid cells (ILC2s) are generally considered to have pro-tumor functions. However, Belz and colleagues demonstrate that ILC2s have anti-melanoma effects due to their high production of the inflammatory cytokine granulocyte-macrophage colony-stimulating factor in the tumor microenvironment.

Nicolas Jacquelot
Cyril Seillet
Gabrielle T. Belz
Research07 Jun 2021
Nature Immunology

Volume: 22, P: 851-864
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease

M R Starkey
D H Nguyen
P M Hansbro
Research18 Sept 2013
Mucosal Immunology

Volume: 7, P: 478-488
Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease

M R Starkey
A T Essilfie
P M Hansbro
Research07 Nov 2012
Mucosal Immunology

Volume: 6, P: 569-579
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization

M J Gold
P R Hiebert
J A Hirota
Research01 May 2016
Mucosal Immunology

Volume: 9, P: 809-820
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

S Keely
E L Campbell
S P Colgan
Research22 May 2013
Mucosal Immunology

Volume: 7, P: 114-123
A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease

T J Haw
M R Starkey
P M Hansbro
Research11 Nov 2015
Mucosal Immunology

Volume: 9, P: 859-872
Animal and translational models of SARS-CoV-2 infection and COVID-19

M. D. Johansen
A. Irving
P. M. Hansbro
Reviews20 Aug 2020
Mucosal Immunology

Volume: 13, P: 877-891
Pulmonary-intestinal cross-talk in mucosal inflammatory disease

S Keely
N J Talley
P M Hansbro
Reviews16 Nov 2011
Mucosal Immunology

Volume: 5, P: 7-18
Restricted access or access all areas? a new cadherin-like protein upregulated in the inflamed esophagus

D A Knight
P M Hansbro
Comments & Opinion20 Dec 2017
Mucosal Immunology

Volume: 11, P: 1-2

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Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

Neutron diffraction reveals the orientation of the headgroup of inositol lipids in model membranes

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease

Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease

Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease

Animal and translational models of SARS-CoV-2 infection and COVID-19

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

Restricted access or access all areas? a new cadherin-like protein upregulated in the inflamed esophagus

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