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Showing 51–100 of 191 results
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  • Lamin A/C protects alveolar macrophages against nuclear envelope rupture and DNA damage, but it erodes during aging. Lack of lamin A/C leads to senescence and an aging signature, resulting in vulnerability to influenza virus and lung cancer growth.

    • Nilushi S. De Silva
    • Johan Siewiera
    • Nicolas Manel
    Research
    Nature Aging
    Volume: 3, P: 1251-1268
  • Life is homochiral, and prior work posited that D-RNA may interact preferentially with L-amino acids. Here, the authors show that self-aminoacylating D-RNAs do not have an intrinsic preference for L-amino acids, suggesting that either handedness could emerge from early living systems.

    • Josh Kenchel
    • Alberto Vázquez-Salazar
    • Irene A. Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9
  • Dry season rainfall in the Amazon is projected by constraining global climate models with simple models calibrated to observations. The results indicate a longer dry season over a larger area and a strengthening of the monsoon season this century.

    • Juan P. Boisier
    • Philippe Ciais
    • Matthieu Guimberteau
    Research
    Nature Climate Change
    Volume: 5, P: 656-660
  • We present James Webb Space Telescope observations that detect the 3.3 μm polycyclic aromatic hydrocarbon feature in a galaxy observed less than 1.5 billion years after the Big Bang.

    • Justin S. Spilker
    • Kedar A. Phadke
    • Katherine E. Whitaker
    Research
    Nature
    Volume: 618, P: 708-711
  • Mutations in CNTNAP2 have been associated with a syndromic form of Autism Spectrum Disorder. Here the authors show that forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of ASD with a homozygous truncating mutation in CNTNAP2 displayed an increase in volume and total cell number, which is driven by abnormal cellular proliferation and neurogenesis.

    • Job O. de Jong
    • Ceyda Llapashtica
    • Sander Markx
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • In situ experimental findings from six contrasting oceanic regimes, at multiple mesopelagic depths, are used to determine the mechanisms that drive microbially mediated carbon flux attenuation in the oceanic biological pump.

    • M. Bressac
    • E. C. Laurenceau-Cornec
    • P. W. Boyd
    ResearchOpen Access
    Nature
    Volume: 633, P: 587-593
  • The approximately 5-Gb tuatara (Sphenodon punctatus) genome assembly provides a resource for analysing amniote evolution, and highlights the imperative for meaningful cultural engagement with Indigenous communities in genome-sequencing endeavours.

    • Neil J. Gemmell
    • Kim Rutherford
    • Haydn Edmonds
    ResearchOpen Access
    Nature
    Volume: 584, P: 403-409
  • Thermal transitions of polyisocyanide single molecules to polymer bundles and finally networks lead to hydrogels mimicking the properties of biopolymer intermediate-filament networks; their analysis shows that bundling and chain stiffness are crucial design parameters for hydrogels.

    • Paul H. J. Kouwer
    • Matthieu Koepf
    • Alan E. Rowan
    Research
    Nature
    Volume: 493, P: 651-655
  • PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assays

    • Abdellah Allali-Hassani
    • Magdalena M. Szewczyk
    • Masoud Vedadi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11
  • High-resolution imaging techniques show that aromatic amino acids such as tryptophan formed abiotically and were subsequently preserved at depth beneath the Atlantis Massif of the Mid-Atlantic Ridge, supporting the hydrothermal theory for the origin of life.

    • Bénédicte Ménez
    • Céline Pisapia
    • Matthieu Réfrégiers
    Research
    Nature
    Volume: 564, P: 59-63
  • In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulations recapitulate the restricted diffusion characteristics of OMPs.

    • Matthieu Chavent
    • Anna L. Duncan
    • Mark S. P. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural basis for a coordinated chemo-mechanical kinesin translocation model.

    • Matthieu P.M.H. Benoit
    • Ana B. Asenjo
    • Hernando Sosa
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21
  • Discriminating between active and latent infection with Mycobacterium tuberculosis (Mtb) is a protracted and complicated process, which can affect the timeliness of treatment decisions. Harari et al. now report that the cytokine profiles of Mtb-specific CD4+ T cells characterized by a polychromatic flow cytometry assay can distinguish latent infection from active disease.

    • Alexandre Harari
    • Virginie Rozot
    • Giuseppe Pantaleo
    Research
    Nature Medicine
    Volume: 17, P: 372-376
  • Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.

    • Matthew P. Parsons
    • Matthieu P. Vanni
    • Lynn A. Raymond
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12
  • The genome of the gibbon, a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes, is presented, providing insights into the evolutionary history of gibbon species and their accelerated karyotypes, as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees.

    • Lucia Carbone
    • R. Alan Harris
    • Richard A. Gibbs
    ResearchOpen Access
    Nature
    Volume: 513, P: 195-201
  • mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.

    • Martina Bonucci
    • Nicolas Kuperwasser
    • Mario Pende
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Previously, a proof-of-concept for low frequency synthetic apomixis was established in a laboratory strain of rice by combining MiMe mutations with the egg cell expression of the embryogenic trigger - BBM1. Here, the authors achieve clonal seed formation in hybrid rice with almost full penetrance and higher fertility.

    • Aurore Vernet
    • Donaldo Meynard
    • Emmanuel Guiderdoni
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • Semiconducting armchair graphene nanoribbons with sub-10 nm width are of great technological importance but yet to realize. Here, the authors report growth of such nanoribbons on germanium and controlled crystallographic orientation and well-defined armchair edges are obtained.

    • Robert M. Jacobberger
    • Brian Kiraly
    • Michael S. Arnold
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8
  • Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.

    • Sebastian Scheer
    • Suzanne Ackloo
    • Cheryl H. Arrowsmith
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14
  • Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of the sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses define key evolutionary events in vertebrate lineages and provide evidence for two whole-genome duplication events occurring before the divergence of the ancestral lamprey and jawed vertebrate (gnathostome) lineages.

    • Jeramiah J Smith
    • Shigehiro Kuraku
    • Weiming Li
    ResearchOpen Access
    Nature Genetics
    Volume: 45, P: 415-421
  • Diverse macrophage subsets are found in adipose tissue where they regulate its physiology. Here, the authors used single-cell RNA sequencing to analyse the effect of post-prandial lipids on adipose tissue macrophages and identify Tim4 as a regulator of ABCA1+ macrophage function and post-prandial cholesterol transport.

    • M. S. Magalhaes
    • P. Smith
    • C. Bénézech
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
    • P. M. Rattansi
    Books & Arts
    Nature
    Volume: 280, P: 616
  • Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

    • Aled M. Edwards
    • Dafydd R. Owen
    • Suzanne Ackloo
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 634-645
  • Functional imaging in awake head-fixed mice is a widely used technique to study neural responses. Here the authors report on an open source, fully automated unsupervised system for training mice to self initiate head fixation to enable stable mesoscopic functional imaging of cortical functional connectivity.

    • Timothy H. Murphy
    • Jamie D. Boyd
    • Jeff M. LeDue
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12
  • Rift Valley fever is a zoonotic haemorrhagic fever with complex transmission dynamics influenced by environmental variables and animal movements. Here, the authors develop a metapopulation model incorporating these factors and use it to identify the main drivers of transmission in the Comoros archipelago.

    • Warren S. D. Tennant
    • Eric Cardinale
    • Raphaëlle Métras
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • Ultrafast nonadiabatic chemical dynamics during molecular photo-transformations remain challenging to describe since electronic/nuclear configurations are coupled. Here the authors use time-resolved X-ray absorption spectroscopy to probe the light-induced spin-state trapping dynamics of [Fe(bpy)3]2+beyond the Born-Oppenheimer approximation.

    • Henrik T. Lemke
    • Kasper S. Kjær
    • Marco Cammarata
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8
  • Potential energy landscape models are often used to describe transitions in the glassy state. Here, the authors report that the landscape is much rougher than usually assumed, and demonstrate that it undergoes a transition to fractal basins before the jamming point is reached.

    • Patrick Charbonneau
    • Jorge Kurchan
    • Francesco Zamponi
    Research
    Nature Communications
    Volume: 5, P: 1-6
  • A chromosome conformation capture method in which single cells are first imaged and then processed enables intact genome folding to be studied at a scale of 100 kb, validated, and analysed to generate hypotheses about 3D genomic interactions and organisation.

    • Tim J. Stevens
    • David Lando
    • Ernest D. Laue
    Research
    Nature
    Volume: 544, P: 59-64
  • The structure of turbidity currents has remained unresolved mainly due to lack of observations. Here the authors present data from a high-resolution monitoring array deployed for 18 months over Monterey Bay, that suggests turbidity currents are driven by dense near-bed layers.

    • Charles K. Paull
    • Peter J. Talling
    • Matthieu J. Cartigny
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9
  • In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 — in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models.

    • Helge Gad
    • Tobias Koolmeister
    • Thomas Helleday
    Research
    Nature
    Volume: 508, P: 215-221
  • Environmental variability is one potential driver of behavioural and cultural diversity in humans and other animals. Here, the authors show that chimpanzee behavioural diversity is higher in habitats that are more seasonal and historically unstable, and in savannah woodland relative to forested sites.

    • Ammie K. Kalan
    • Lars Kulik
    • Hjalmar S. Kühl
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • Kinesin-13s are microtubule depolymerases that lack motile activity. Here the authors present the cryo-EM structures of kinesin-13 microtubule complexes in different nucleotide bound states, which reveal how ATP hydrolysis is linked to conformational changes and propose a model for kinesin induced depolymerisation.

    • Matthieu P.M.H. Benoit
    • Ana B. Asenjo
    • Hernando Sosa
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • Engineering the interaction between spin and charge is important for the creation of spintronics devices. Here, the authors show that the Rashba effect at a single crystalline Fe/Ge(111) interface produces enhanced spin-charge conversion, which could help develop a spin field-effect-transistor.

    • S. Oyarzún
    • A. K. Nandy
    • M. Jamet
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9