Cofilin, a ubiquitous 15,000 Mr protein, plays a central role in regulating cytoskeletal dynamics. Cofilin binds to act in monomers and filaments, and has a pH-dependent actin severing activity. The structure will allow for a detailed analysis of cof ilin function.
- A.A. Fedorov
- P. Lappalainen
- S.C. Almo