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The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion and long-range signalling of the embryonic development morphogen Hedgehog.

Tamás Matusek
Franz Wendler
Pascal P. Thérond
Research03 Dec 2014
Nature

Volume: 516, P: 99-103
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

Laurent Ruel
Ralph Rodriguez
Pascal P. Thérond
Research01 Oct 2003
Nature Cell Biology

Volume: 5, P: 907-913
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

Thomas Préat
Pascal Thérond
Denise Busson
Research06 Sept 1990
Nature

Volume: 347, P: 87-89
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex

In Drosophila, protein kinase A (PKA) phosphorylates the transcription factor Cubitus interruptus (Ci) in the absence of Hedgehog signalling and the transducer Smoothened in its presence. Here, the authors investigate the mechanism underlying this switch and propose that Smoothened outcompetes Ci for association with PKA on Hedgehog signalling activation.

Nadia Ranieri
Pascal P. Thérond
Laurent Ruel
Research07 Oct 2014
Nature Communications

Volume: 5, P: 1-14
The mechanisms of Hedgehog signalling and its roles in development and disease

The founding member of the Hedgehog (HH) family of secreted proteins was cloned two decades ago. The mechanism of HH signalling is incomplete, but insight has been gained into the function of lipidation in ligand secretion and transport, as well as into key components of the signalling pathway.

James Briscoe
Pascal P. Thérond
Reviews30 May 2013
Nature Reviews Molecular Cell Biology

Volume: 14, P: 416-429
Gli genes in development and cancer

Michael P Matise
Alexandra L Joyner
Research04 Jan 2000
Oncogene

Volume: 18, P: 7852-7859
LOW VITAMINE A INTAKE IN CHILDREN WITH SHORT STATURE

P Evain-Brion
A Paulsen
P Czernichow
Research01 May 1993
Pediatric Research

Volume: 33, P: S63

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The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex

The mechanisms of Hedgehog signalling and its roles in development and disease

Gli genes in development and cancer

LOW VITAMINE A INTAKE IN CHILDREN WITH SHORT STATURE

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