Nature Search

Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

Smith et al. report that age-associated mutations in mitochondrial DNA cause defects in oxidative phosphorylation. This results in metabolic rewiring, which subsequently contributes to accelerated development of colorectal cancer.

Anna L. M. Smith
Julia C. Whitehall
Laura C. Greaves
Research21 Sept 2020
Nature Cancer

Volume: 1, P: 976-989
Differential SPARC mRNA expression in Barrett's oesophagus

J Brabender
R V Lord
P M Schneider
ResearchOpen Access14 Oct 2003
British Journal of Cancer

Volume: 89, P: 1508-1512
UCP1 governs liver extracellular succinate and inflammatory pathogenesis

UCP1 is exclusively expressed in brown and beige adipocytes, where it drives thermogenesis through futile substrate cycling. Mills et al. identify a endocrine pathway mediated by the UCP1 catabolic circuit that antagonizes liver inflammation by lowering the concentration of succinate in the liver extracellular fluid.

Evanna L. Mills
Cathal Harmon
Edward T. Chouchani
Research17 May 2021
Nature Metabolism

Volume: 3, P: 604-617
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

John P. McGrath
Alexander Varshavsky
Research03 Aug 1989
Nature

Volume: 340, P: 400-404
Thermal Regulation in Sail Lizards

C. D. BRAMWELL
P. B. FELLGETT
Research16 Mar 1973
Nature

Volume: 242, P: 203-205
Earth’s ambipolar electrostatic field and its role in ion escape to space

The ambipolar field of Earth controls the structure of the polar ionosphere and boosts its scale height by 271%, physically driving the polar wind and acting as the source of the magnetospheric cold H⁺ ion population.

Glyn A. Collinson
Alex Glocer
E. Zesta
Research28 Aug 2024
Nature

Volume: 632, P: 1021-1025
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Author Correction: CryoET reveals actin filaments within platelet microtubules

Chisato Tsuji
Marston Bradshaw
Mark P. Dodding
Amendments and CorrectionsOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1
Enteral feeding reduces metabolic activity of the intestinal microbiome in Crohn’s disease: an observational study

C Walton
M P B Montoya
J O Hunter
Research11 May 2016
European Journal of Clinical Nutrition

Volume: 70, P: 1052-1056
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.

Dinesh Aggarwal
Andrew J. Page
Ewan M. Harrison
ResearchOpen Access23 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex

Daniel P. Gold
Jennifer M. Puck
Cox Terhorst
Amendments and Corrections18 Dec 1986
Nature

Volume: 324, P: 702
TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression

M Seux
S Peuget
N J Dusetti
Research21 Feb 2011
Oncogene

Volume: 30, P: 3049-3061
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

SHP2 interacts with ACK1 kinase to erase pY54-H3 (Tyr54-phosphorylation of histones H3) epigenetic marks and triggers Androgen receptor transcriptional program. It explains genital abnormalities and infertility in LEOPARD syndrome patients, and AR upregulation in prostate cancer.

Surbhi Chouhan
Dhivya Sridaran
Nupam P. Mahajan
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Genetic variation in space and time in a population of ponderosa pine

Y B Linhart
J B Mitton
M L Davis
Research01 Jun 1981
Heredity

Volume: 46, P: 407-426
Thermally conductive ultra-low-k dielectric layers based on two-dimensional covalent organic frameworks

Low-k dielectric materials are essential to allow continued electronics miniaturization, but their low thermal conductivity limits performance. Here, two-dimensional covalent organic frameworks are shown to combine high thermal conductivity with a low dielectric constant.

Austin M. Evans
Ashutosh Giri
Patrick E. Hopkins
Research18 Mar 2021
Nature Materials

Volume: 20, P: 1142-1148
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Mycobacterium leprae-specific protein antigens defined by cloned human helper T cells

T. H. M. Ottenhoff
P. R. Klatser
R. R. P. de Vries
Amendments and Corrections01 Jan 1986
Nature

Volume: 319, P: 427
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Ontogenesis of Nerve Growth Factor and Epidermal Growth Factor in Submaxillary Glands and Nerve Growth Factor in Brains of Immature Male Mice: Correlation with Ontogenesis of Serum Levels of Thyroid Hormones

P Walker
M E Weichsel Jr.
D A Fisher
Research01 Jul 1982
Pediatric Research

Volume: 16, P: 520-524
Contrasting impacts of pollen and seed dispersal on spatial genetic structure in the bird-pollinated Banksia hookeriana

S L Krauss
T He
M E Hanley
Research12 Nov 2008
Heredity

Volume: 102, P: 274-285
Transverse emittance reduction in muon beams by ionization cooling

Current muon beams have a phase-space volume that is too large for applications in muon colliders. Now, the reduction in the beam’s transverse emittance when passed through different absorbers in ionization cooling experiments is quantified.

M. Bogomilov
R. Tsenov
C. Heidt
ResearchOpen Access17 Jul 2024
Nature Physics

Volume: 20, P: 1558-1563
Proteomic analyses do not reveal subclinical inflammation in fatigued patients with clinically quiescent inflammatory bowel disease

Arno R. Bourgonje
Sietse J. Wichers
Lieke M. Spekhorst
ResearchOpen Access26 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
Reduced chromatin accessibility correlates with resistance to Notch activation

Notch signalling plays a key role in cell fate transitions, but how Notch activates distinct regulatory networks in closely related cell types is not well understood. Here the authors profile Notch and RBPJ targets in the developing mouse cortex and reveal how transcription factor occupancy and chromatin remodelling interact to direct differential gene expression during differentiation.

Jelle van den Ameele
Robert Krautz
Andrea H. Brand
ResearchOpen Access25 Apr 2022
Nature Communications

Volume: 13, P: 1-10
Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trial

Immunotherapy with immune checkpoint inhibitors and targeted therapy with BRAF and MEK inhibition have revolutionized the treatment of melanoma. Here the authors report the results of a phase II trial of neoadjuvant cobimetinib (MEK inhibitor) and atezolizumab (anti-PD-L1) with or without the BRAF inhibitor vemurafenib in patients with resectable Stage III melanoma.

Tina J. Hieken
Garth D. Nelson
Matthew S. Block
ResearchOpen Access16 Feb 2024
Nature Communications

Volume: 15, P: 1-12
The dental status of a group of diabetic children

A R Faulconbridge
W C Bradshaw
J D Baum
Research20 Oct 1981
British Dental Journal

Volume: 151, P: 253-255
Efficient generation of energetic ions in multi-ion plasmas by radio-frequency heating

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

Ye. O. Kazakov
J. Ongena
I. Zychor
Research19 Jun 2017
Nature Physics

Volume: 13, P: 973-978
Survival of TP53-mutated acute myeloid leukemia patients receiving allogeneic stem cell transplantation after first induction or salvage therapy: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)

Talha Badar
Ehab Atallah
Mark R. Litzow
Research18 Feb 2023
Leukemia

Volume: 37, P: 799-806
A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients

Debbie S. Deben
Rob H. Creemers
Dennis R. Wong
ResearchOpen Access22 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine

M M T J Broekman
D R Wong
D J de Jong
Research03 Jan 2017
The Pharmacogenomics Journal

Volume: 18, P: 160-166
An Agrobacterium transformation in the evolution of the genus Nicotiana

Ian J. Furner
Gary A. Huffman
Eugene W. Nester
Research01 Jan 1986
Nature

Volume: 319, P: 422-427
Humans and seasonal climate variability threaten large-bodied coral reef fish with small ranges

Knowing which species traits may confer resilience to human-mediated stressors will help predict future impacts on biodiversity. Here, Mellin et al. show that large bodied fish with small geographic ranges are disproportionately affected by the negative impacts of human disturbance and climate variability.

C. Mellin
D. Mouillot
M. J. Caley
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-9
The DNA sequence of human chromosome 22

I. Dunham
A. R. Hunt
K. P. O'Brien
Research02 Dec 1999
Nature

Volume: 402, P: 489-495
A randomized controlled trial of restorative justice-informed treatment for domestic violence crimes

Using a randomized design over 24 months, Mills et al. show that the addition of restorative-justice-informed practices to a typical treatment for domestic violence crimes leads to substantial reductions in new arrests and crime severity scores.

Linda G. Mills
Briana Barocas
Barak Ariel
Research23 Sept 2019
Nature Human Behaviour

Volume: 3, P: 1284-1294
A liquid permanent magnet confirmed

P. V. E. McClintock
News & Views20 Apr 1978
Nature

Volume: 272, P: 671-672
Modulation of Intestinal Epithelial Permeability by Plasma from Patients with Crohn’s Disease in a Three-dimensional Cell Culture Model

Pan Xu
Elhaseen Elamin
Daisy M. A. E. Jonkers
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Lisa Dowling
Philip Jakeman
Colum P. Dunne
ResearchOpen Access28 Sept 2021
Scientific Reports

Volume: 11, P: 1-8
Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans

R Pacella-Norman
M I Urban
V Beral
ResearchOpen Access07 Jun 2002
British Journal of Cancer

Volume: 86, P: 1751-1756
The DNA sequence of human chromosome 7

LaDeana W. Hillier
Robert S. Fulton
Richard K. Wilson
Research10 Jul 2003
Nature

Volume: 424, P: 157-164
Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

A minimal matrix model of scars is shown to elicit scar-like phenotypes from mesenchymal stem cells and to exhibit less cell-to-cell noise than homogeneously stiff gels, owing to the slow nuclear exit of a scar-marker mechanorepressor.

P. C. Dave P. Dingal
Andrew M. Bradshaw
Dennis E. Discher
Research13 Jul 2015
Nature Materials

Volume: 14, P: 951-960
Mechanism of adrenergic Ca_V1.2 stimulation revealed by proximity proteomics

An in vivo approach to identify proteins whose enrichment near cardiac Ca_V1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca²⁺ current.

Guoxia Liu
Arianne Papa
Steven O. Marx
Research22 Jan 2020
Nature

Volume: 577, P: 695-700
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.

Laura Broutier
Gianmarco Mastrogiovanni
Meritxell Huch
Research13 Nov 2017
Nature Medicine

Volume: 23, P: 1424-1435
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

Identifying DNA sequences that adopt alternative structures within the context of genomic DNA presents a major challenge. Pyridostatin, a G-quadruplex–specific chemical probe, was shown to induce DNA damage at specific genomic sites, including the proto-oncogene SRC, leading to cell cycle arrest in human cancer cells.

Raphaël Rodriguez
Kyle M Miller
Stephen P Jackson
Research05 Feb 2012
Nature Chemical Biology

Volume: 8, P: 301-310
Expanded TCRβ CDR3 clonotypes distinguish Crohn’s disease and ulcerative colitis patients

J. Wu
A. H. Pendegraft
P. J. Mannon
Research09 Jul 2018
Mucosal Immunology

Volume: 11, P: 1487-1495
Relationship between allozyme heterozygosity and biomass production in jack pine (Pinus banksiana Lamb.) under different environmental conditions

D R Govindaraju
B P Dancik
Research01 Oct 1986
Heredity

Volume: 57, P: 145-148
DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells

V Trapani
V Patel
A I Loaiza-Pérez
ResearchOpen Access18 Feb 2003
British Journal of Cancer

Volume: 88, P: 599-605
Current best practice for disease activity assessment in IBD

Objective assessment of disease activity in IBD is crucial for successfully guiding therapy. Here, the authors comprehensively evaluate disease activity indices for their use in clinical practice and clinical trials, as well as assessing relevant biomarkers and measures of quality of life.

Alissa J. Walsh
Robert V. Bryant
Simon P. L. Travis
Reviews01 Sept 2016
Nature Reviews Gastroenterology & Hepatology

Volume: 13, P: 567-579
Sir A. B. Kempe, F.R.S

P. A. M.
Comments & Opinion06 May 1922
Nature

Volume: 109, P: 588-589
Flying the flag

P. F. R. Little
Comments & Opinion28 Sept 1989
Nature

Volume: 341, P: 358

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