Prodiginines are a family of secondary metabolites produced by Gram-positive and Gram-negative bacteria that have anticancer and immunosuppressive activities. The biosynthesis of these tripyrrole red pigments is reviewed, together with a discussion of the exquisite regulation of the production of these molecules, and why bacteria might benefit from producing such complex products.
- Neil R. Williamson
- Peter C. Fineran
- George P. C. Salmond