Generating and detecting neutral biomolecular beams is an important analytical challenge, particularly for high-mass peptides. Here, femtosecond laser desorption is shown to enable the intact volatilization of complex polypeptides that can still be photoionized at masses beyond 20 kDa, because they are tryptophan-rich.
- Jonas Schätti
- Philipp Rieser
- Markus Arndt