Guillain–Barré syndrome (GBS) is a postinfectious disease characterized by rapidly progressive, symmetrical weakness of the extremities, and can lead to life-threatening complications such as respiratory insufficiency and autonomic dysfunction. Here, van den Berg et al. describe the immune pathogenesis and clinical characteristics of GBS and its subtypes, and highlight the importance of careful diagnostic assessment of patients and the possible additional diagnostic value of cerebrospinal fluid examinations and nerve conduction tests. The authors review treatment options and prognosis, including novel predictive models, for patients with GBS.
- Bianca van den Berg
- Christa Walgaard
- Pieter A. van Doorn