The recent determination of several crystal structures of G protein-coupled receptors (GPCRs) is providing new opportunities for structure-based drug design. This article analyses the state of the art in the prediction of GPCR structure and the docking of potential ligands on the basis of a community-wide, blind prediction assessment — GPCR Dock 2008 — that was carried out in coordination with the publication of the human adenosine A2Areceptor structure in 2008 and public release of the three-dimensional coordinates.
- Mayako Michino
- Enrique Abola
- Raymond C. Stevens
