Nature Search

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

The authors use high-throughput histology to construct three-dimensional maps of the vascular architecture throughout mouse vibrissal cortex. Modeling of the vascular networks revealed that microvessels are highly interconnected; do not form functional 'modules', as previously suggested; and lead to flow patterns that explain the origin of single vessel strokes.

Pablo Blinder
Philbert S Tsai
David Kleinfeld
Research09 Jun 2013
Nature Neuroscience

Volume: 16, P: 889-897
Chronic optical access through a polished and reinforced thinned skull

A polished and reinforced thinned-skull procedure is used to create a large, chronically stable window in the skull that allows repeated imaging of cortical structures as well as optically guided physiological manipulation. It is proposed as an alternative to the craniotomy and current thinned-skull methods.

Patrick J Drew
Andy Y Shih
David Kleinfeld
Research21 Oct 2010
Nature Methods

Volume: 7, P: 981-984
The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

The authors utilize optical occlusion of penetrating blood vessels to induce cortical microinfarcts. Occlusion of even a single such vessel leads to behavioral dysfunction, whereas multiple, yet sparse, occlusions can induce substantial tissue damage. Excitotoxicity blockers ameliorate both effects.

Andy Y Shih
Pablo Blinder
David Kleinfeld
Research16 Dec 2012
Nature Neuroscience

Volume: 16, P: 55-63
The pial vasculature of the mouse develops according to a sensory-independent program

Matthew D. Adams
Aaron T. Winder
Patrick J. Drew
ResearchOpen Access29 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo

Yona Goldshmit
Rita Perelroizen
Angela Ruban
ResearchOpen Access19 Jul 2021
Scientific Reports

Volume: 11, P: 1-15

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The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

Chronic optical access through a polished and reinforced thinned skull

The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit

The pial vasculature of the mouse develops according to a sensory-independent program

Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo

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