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A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

A panel of urinary biomarkers enables the progression of renal injury and subsequent repair and recovery to be monitored after exposure of rats to either carbapenem A or gentamicin. The authors complement this study by demonstrating that serum cystatin C is more sensitive and specific than serum creatinine and blood urea nitrogen in monitoring generalized renal function after exposure to nephrotoxicants.

Josef S Ozer
Frank Dieterle
David L Gerhold
Research10 May 2010
Nature Biotechnology

Volume: 28, P: 486-494
Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury

Current biomarkers for detecting kidney damage, such as serum creatinine (SCr) and blood urea nitrogen (BUN), lack the sensitivity needed for use in drug development. Urinary clusterin outperforms SCr and BUN in detecting proximal tubular injury, and urinary total protein, cystatin C and β2-microglobulin each outperform either SCr or BUN in detecting glomerular injury.

Frank Dieterle
Elias Perentes
Gérard Maurer
Research10 May 2010
Nature Biotechnology

Volume: 28, P: 463-469
Characterisation of the blood RNA host response underpinning severity in COVID-19 patients

Heather Jackson
Irene Rivero Calle
Calviño-Suárez Cristina
ResearchOpen Access17 Jul 2022
Scientific Reports

Volume: 12, P: 1-14

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