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Advanced filters: Author: Padmini Jayaraman Clear advanced filters

  • In response to microbial ligands, IRF5 promotes pro-inflammatory M1 macrophage activation and production of nitrous oxide. Here the authors show that nitrous oxide modifies IRF5 tyrosine residues as a negative feedback, limiting the inflammatory response and protecting from endotoxin shock.

    • Geming Lu
    • Ruihua Zhang
    • Huabao Xiong
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14