Ion channels are attractive therapeutic targets for a wide range of diseases, but achieving sufficient selectivity with small-molecule drugs can be challenging. In this Review, Wulff and colleagues discuss strategies to selectively modulate ion channel function using biologics — namely, antibodies and venom-derived peptides — highlighting opportunities, hurdles and future directions for the field.
- Heike Wulff
- Palle Christophersen
- Vladimir Yarov-Yarovoy
