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Showing 1–3 of 3 results
Advanced filters: Author: Pamela Caudana Clear advanced filters

  • Understanding CD8 + T cell response to immune checkpoint blockade at the molecular level is important for the design of more efficient cancer immune therapies. Authors show here that the histone lysine methyltransferase Suv39h1 controls the transcriptional programs that determine the functionality of CD8 + T cells and Suv39h1 inhibition may potentiate anti-PD-1 therapy of melanomas.

    • Leticia Laura Niborski
    • Paul Gueguen
    • Eliane Piaggio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.

    • Louis Pérol
    • John M. Lindner
    • Eliane Piaggio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10