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Showing 1–5 of 5 results
Advanced filters: Author: Pamela Magistrado Clear advanced filters

  • Piperaquine (PPQ) resistance of Plasmodium is an increasing problem. Here, Bopp et al. find a bimodal dose−response curve of Cambodian isolates exposed to PPQ, with the area under the curve correlating with in vitro PPQ resistance, and show the importance of Plasmepsin II–III copy number to PPQ resistance.

    • Selina Bopp
    • Pamela Magistrado
    • Sarah K. Volkman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al.investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decrease susceptibility to a diverse set of 50 antimalarial compounds.

    • Victoria C. Corey
    • Amanda K. Lukens
    • Elizabeth A. Winzeler
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The emergence of resistant Plasmodiumstrains fuels the search for new antimalarials. Here, the authors present a new class of potent antimalarial compounds, the triaminopyrimidines, that display low toxicity and long half-life in animal models.

    • Shahul Hameed P.
    • Suresh Solapure
    • Vasan K. Sambandamurthy
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11