Unlike somatic cells, stem cells persist throughout life, which may increase their risk of accumulating DNA damage. recent studies indicate that stem cells use different mechanisms (such as the error-prone non-homologous end joining pathway) from somatic cells to maintain genomic integrity, which could have deleterious consequences for their long-term function.
- Pankaj K. Mandal
- Cédric Blanpain
- Derrick J. Rossi
