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Showing 1–3 of 3 results
Advanced filters: Author: Paola Agüi-Gonzalez Clear advanced filters

  • Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.

    • Martin Meschkat
    • Anna M. Steyer
    • Wiebke Möbius
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis. Here, the authors show an alternative molecular recycling mechanism that occurs for the key ECM protein Tenascin-R.

    • Tal M. Dankovich
    • Rahul Kaushik
    • Silvio O. Rizzoli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-23