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Showing 1–2 of 2 results
Advanced filters: Author: Paola Bartoccioni Clear advanced filters
  • Asc1/CD98hc is a key regulator of small neutral amino acid transport in the brain and adipose tissue. Here, authors report the structure of semi-occluded hAsc1/CD98hc and provide a model for Asc1 exchange and facilitated diffusion modes of transport.

    • Josep Rullo-Tubau
    • Maria Martinez-Molledo
    • Oscar Llorca
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • L-Amino acid Transporters (LATs) are asymmetric amino acid exchangers. Here the authors determine the crystal structure of a prokaryotic LAT, the alanine-serine-cysteine exchanger (BasC) and identify key residues for asymmetric substrate interaction in both BasC and the homologous human transporter Asc-1 through functional studies.

    • Ekaitz Errasti-Murugarren
    • Joana Fort
    • Manuel Palacín
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12