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Showing 1–3 of 3 results
Advanced filters: Author: Paola Cornejo-Paramo Clear advanced filters

  • Here the authors report that enhancers appear more often in late-replicating DNA regions and are enriched for mutations affecting TF binding. This relationship with DNA replication time is seen in species evolution and cancer, suggesting a fundamental principle of genome evolution.

    • Paola Cornejo-Páramo
    • Veronika Petrova
    • Emily S. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Alberto Orta et al. demonstrate that frequent mosaic loss of chromosome Y (LOY) observed in aging men might also be present in rats. They show that, like in humans, LOY in rats is associated with aging, but is not dependent on environmental stressors, and may be a natural process in placental mammals.

    • Alberto H. Orta
    • Stephen J. Bush
    • Diego Cortez
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-8