Nature Search

Learning curve for robotic-assisted hiatal hernia repair determined by cumulative analysis of adjusted operative times

Lautaro Gonzalez Stefani
Francesco Mongelli
Fabiano Iaquinandi
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Quality of life in low-risk prostate cancer under active surveillance or following radical treatments: the START cohort study

Rosalba Rosato
Stefano De Luca
Andrea Di Stasio
ResearchOpen Access16 Oct 2025
Prostate Cancer and Prostatic Diseases

P: 1-9
X–linked thrombocytopenia and Wiskott–Aldrich syndrome are allelic diseases with mutations in the WASP gene

Anna Villa
Luigi Notarangelo
Paolo Vezzoni
Research01 Apr 1995
Nature Genetics

Volume: 9, P: 414-417
Electoral ploy?

Paolo Amati
Correspondence27 Aug 1992
Nature

Volume: 358, P: 706
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

Paolo Macchi
Anna Villa
Luigi D. Notarangelo
Research07 Sept 1995
Nature

Volume: 377, P: 65-68
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency

William A Irwin
Natascha Bergamin
Paolo Bonaldo
Research16 Nov 2003
Nature Genetics

Volume: 35, P: 367-371
Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration

Autophagy is often believed to be elevated in disease, contributing to pathogenesis. Paolo Bonaldo and his colleagues now show that it is actually too little autophagy that occurs in some forms of muscular dystrophy, resulting in the continued presence of defective mitochondria and thus myofiber degeneration. They also show that increasing autophagy via dietary or pharmacological means can ameliorate muscle pathology in a mouse model of human muscular dystrophy.

Paolo Grumati
Luisa Coletto
Paolo Bonaldo
Research31 Oct 2010
Nature Medicine

Volume: 16, P: 1313-1320
Dinosaur diversification linked with the Carnian Pluvial Episode

Dinosaurs originated ~245 million years ago (mya) but did not diversify until some time in the Late Triassic. Here, Bernardi and colleagues synthesize palaeontological and dated stratigraphic evidence to show that dinosaur diversification followed the Carnian Pluvial Episode 234–232 mya.

Massimo Bernardi
Piero Gianolla
Michael J. Benton
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia

Barbara Picconi
Diego Centonze
Paolo Calabresi
Research31 Mar 2003
Nature Neuroscience

Volume: 6, P: 501-506
Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia

Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease progression in mouse leukaemia xenograft models.

Michela Consonni
Claudio Garavaglia
Giulia Casorati
ResearchOpen Access11 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Fidia and neuroscience

Giorgio Bernardi
Giovani Biggio
Giancarlo Pepeu
Correspondence02 Dec 1993
Nature

Volume: 366, P: 399
Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase

The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator, suggesting the existence of distinct but related permeability pathways.

Andrea Carrer
Ludovica Tommasin
Paolo Bernardi
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Purified F-ATP synthase forms a Ca²⁺-dependent high-conductance channel matching the mitochondrial permeability transition pore

The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. Here authors demonstrate that the membrane embedded bovine F-ATP synthase elicits Ca2 + -dependent currents matching those of the MMC/PTP.

Andrea Urbani
Valentina Giorgio
Paolo Bernardi
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-11
The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63

Francesca Bernassola
Andrew Oberst
Pier Paolo Pandolfi
Research27 Jun 2005
Oncogene

Volume: 24, P: 6982-6986
Opposite deletions/duplications of the X chromosome: two novel reciprocal rearrangements

Sabrina Giglio
Barbara Pirola
Orsetta Zuffardi
Research22 Feb 2000
European Journal of Human Genetics

Volume: 8, P: 63-70
Novel perspectives in the management of decompensated cirrhosis

Current approaches to manage decompensated cirrhosis are based on targeted strategies aimed at preventing or treating specific complications of the disease. Here, Bernardi and Caraceni discuss the shift in focus from individual treatments targeting individual complications to disease-modifying agents able to slow the progression of decompensation.

Mauro Bernardi
Paolo Caraceni
Reviews19 Jul 2018
Nature Reviews Gastroenterology & Hepatology

Volume: 15, P: 753-764
Unveiling the origin and functions of diagnostic circulating microRNAs in lung cancer

Tommaso Colangelo
Francesco Mazzarelli
Fabrizio Bianchi
Research04 Apr 2025
British Journal of Cancer

Volume: 132, P: 947-956
Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca²⁺ accumulation in spinobulbar muscular atrophy skeletal muscle

Marchioretti and colleagues show that in the skeletal muscle of SBMA mice and patients there is an early, but reversible alteration of expression of genes involved in muscle contraction and of mitochondrial respiration, followed by accumulation of calcium inside the mitochondria, which is concomitant with the onset of motor dysfunction, and late alteration of muscle structure.

Caterina Marchioretti
Giulia Zanetti
Maria Pennuto
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Mitochondrial H⁺ permeability through the ADP/ATP carrier

Mitochondrial H⁺ leak, which is responsible for basal respiration, appears to be a transport process mediated by the ADP/ATP carrier and regulated by fatty acids and adenine nucleotides.

Paolo Bernardi
News & Views24 Jul 2019
Nature Metabolism

Volume: 1, P: 752-753
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

ERAP1 is an endoplasmic reticulum aminopeptidase that trims MHC Class-I peptides for antigen presentation. Here, the authors show that ERAP1 enhances Hedgehog signalling by sequestering USP47 from βTrCP and promoting tumorigenesis through βTrCP degradation and increased Gli protein stability.

Francesca Bufalieri
Paola Infante
Lucia Di Marcotullio
ResearchOpen Access24 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Adjuvant role of SeptiFast to improve the diagnosis of sepsis in a large cohort of hematological patients

Raffaella Greco
Maria Chiara Barbanti
Fabio Ciceri
Research12 Jan 2018
Bone Marrow Transplantation

Volume: 53, P: 410-416
Prognostic role of masked and white-coat hypertension: 10-Year mortality in treated elderly hypertensives

Francesco Spannella
Andrea Filipponi
Riccardo Sarzani
Research05 Dec 2018
Journal of Human Hypertension

Volume: 33, P: 741-747
PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

The tumour suppressor gene PML is shown to normally restrain angiogenesis, both in tumours and under ischaemic conditions. This involves a new pathway in which during hypoxia, PML regulates mTOR and the transcription factor HIF-1α

Rosa Bernardi
Ilhem Guernah
Pier Paolo Pandolfi
Research17 Aug 2006
Nature

Volume: 442, P: 779-785
PML targeting eradicates quiescent leukaemia-initiating cells

The PML tumour suppressor gene is involved in the development of some forms of leukaemia. New research has identified a role for PML in the quiescence and maintenance of haematopoietic stem cells and of leukaemia-initiating cells. PML can be targeted by arsenic trioxide and was shown to eliminate leukaemia-initiating cells, supporting its use as an anti-leukemia therapy.

Keisuke Ito
Rosa Bernardi
Pier Paolo Pandolfi
Research11 May 2008
Nature

Volume: 453, P: 1072-1078
PML regulates p53 stability by sequestering Mdm2 to the nucleolus

Rosa Bernardi
Pier Paolo Scaglioni
Pier Paolo Pandolfi
Research13 Jun 2004
Nature Cell Biology

Volume: 6, P: 665-672
All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters

Federico Picollo
Alfio Battiato
Valentina Carabelli
ResearchOpen Access09 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Identification of a tumour suppressor network opposing nuclear Akt function

Lloyd C. Trotman
Andrea Alimonti
Pier Paolo Pandolfi
Research07 May 2006
Nature

Volume: 441, P: 523-527
Apoptosis and the laws of thermodynamics

David Nicholls
Paolo Bernardi
Ian Reynolds
Correspondence01 Oct 2000
Nature Cell Biology

Volume: 2, P: E172
Activation of telecom emitters in silicon upon ion implantation and ns pulsed laser annealing

Defected silicon has uses in optically active telecom emitters. Here, nanosecond pulsed laser annealing is demonstrated as a non-invasive, localized method to activate the defects in high-purity silicon substrates.

Greta Andrini
Gabriele Zanelli
Jacopo Forneris
ResearchOpen Access06 Apr 2024
Communications Materials

Volume: 5, P: 1-7
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.

Diego Farinello
Monika Wozińska
Andrea Brendolan
ResearchOpen Access03 May 2018
Nature Communications

Volume: 9, P: 1-12
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

Mitochondrial cristae shape influences apoptosis and respiration. Here the authors show that the mitochondrial fusion protein OPA1 protects mitochondria from dysfunction by promoting ATP synthase oligomerization and reversal activity.

Rubén Quintana-Cabrera
Charlotte Quirin
Luca Scorrano
ResearchOpen Access24 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

The PML tumour suppressor is necessary for the formation of dynamic nuclear organelles called promyelocytic leukaemia nuclear bodies (PML-NBs). Recent data suggest that different PML-NBs may regulate specific cellular functions according to their protein composition, their position in the nucleus and their mobility.

Rosa Bernardi
Pier Paolo Pandolfi
Reviews01 Dec 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 1006-1016
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis

Annalisa Frattini
Paul J. Orchard
Anna Villa
Research01 Jul 2000
Nature Genetics

Volume: 25, P: 343-346
Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age

Pier Paolo Pandolfi
Reviews19 Apr 2004
Oncogene

Volume: 23, P: 3134-3137
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus

Anna Grifa
Carsten A. Wagner
Paolo Gasparini
Correspondence01 Sept 1999
Nature Genetics

Volume: 23, P: 16-18
UCPs — unlikely calcium porters

Paul S. Brookes
Nadeene Parker
Martin D. Brand
Correspondence01 Nov 2008
Nature Cell Biology

Volume: 10, P: 1235-1237
The nucleolus: at the stem of immortality

A nucleolar protein, nucleostemin, is now implicated in the control of stem and cancer cell proliferation. Nucleostemin may modulate p53 function through shuttling between the nucleolus and the nucleoplasm.

Rosa Bernardi
Pier Paolo Pandolfi
News & Views01 Jan 2003
Nature Medicine

Volume: 9, P: 24-25
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

Vivek Swarup
Flora I. Hinz
Daniel H. Geschwind
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 152-164
Concomitant training in robotic and laparoscopic liver resections of low-to-intermediate difficulty score: a retrospective analysis of the learning curve

Lorenzo Bernardi
Emanuele Balzano
Alessandra Cristaudi
ResearchOpen Access13 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Mitochondrial targeting of the p13^II protein coded by the x-II ORF of human T-cell leukemia/lymphotropic virus type I (HTLV-I)

Vincenzo Ciminale
Lorenza Zotti
Luigi Chieco-Bianchi
Research04 Aug 1999
Oncogene

Volume: 18, P: 4505-4514
Dopamine D2 Receptor-Mediated Inhibition of Dopaminergic Neurons in Mice Lacking D2L Receptors

Diego Centonze
Alessandro Usiello
Paolo Calabresi
Research03 May 2002
Neuropsychopharmacology

Volume: 27, P: 723-726
TiO₂–Ag–NP adhesive photocatalytic films able to disinfect living indoor spaces with a straightforward approach

Salvatore Chirumbolo
Davide Gibellini
Umberto Tirelli
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-14
Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

Annalisa Boscolo
Laura Pasin
Rosalba Lembo
ResearchOpen Access06 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Role of nucleophosmin in embryonic development and tumorigenesis

Silvia Grisendi
Rosa Bernardi
Pier Paolo Pandolfi
Research06 Jul 2005
Nature

Volume: 437, P: 147-153
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

Depletion of ribosomal protein S6 leads to upregulation of p53 and cell cycle arrest. Surprisingly, p53 induction is not due to nucleolar disruption and Mdm2 inhibition, but rather the selective translation of a class of mRNAs including ribosomal protein L11.

Stefano Fumagalli
Alessandro Di Cara
George Thomas
Research15 Mar 2009
Nature Cell Biology

Volume: 11, P: 501-508
A role for leukocyte-endothelial adhesion mechanisms in epilepsy

The authors examine how brain inflammation affects the development of epilepsy. They show that genetic or antibody-mediated blockade of leukocyte-vascular interactions reduces epileptogenesis in mice (pages 1309–1310).

Paolo F Fabene
Graciela Navarro Mora
Gabriela Constantin
Research23 Nov 2008
Nature Medicine

Volume: 14, P: 1377-1383
Screening great ape museum specimens for DNA viruses

Michelle Hämmerle
Meriam Guellil
Martin Kuhlwilm
ResearchOpen Access30 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome

Maria Grazia Sacco
Marco Ungari
Paolo Vezzoni
Research01 Oct 2000
Cancer Gene Therapy

Volume: 7, P: 1299-1306
Induction of differentiation and apoptosis by interferon-γ in human neuroblastoma cells in vitro as a dual and alternative early biological response

Paolo Giuseppe Montaldo
Valeria Chiesa
Mirco Ponzoni
Research01 Feb 1997
Cell Death & Differentiation

Volume: 4, P: 150-158
N-terminal cleavage of cyclophilin D boosts its ability to bind F-ATP synthase

Mitochondrial Cyclophilin D can be cleaved at the N-terminus, resulting in a truncated form with enhanced binding to the OSCP subunit of F-ATP Synthase.

Gabriele Coluccino
Alessandro Negro
Giovanna Lippe
ResearchOpen Access11 Nov 2024
Communications Biology

Volume: 7, P: 1-15

Search

Filter By:

Search

Quick links