Nature Search

Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset

Parkinson’s disease is lacking easily accessible biomarkers. Here the authors show, that targeted blood proteomics is feasible to identify the patients and to predict the phenoconvertion in prodromal subjects up to 7 years before symptom onset.

Jenny Hällqvist
Michael Bartl
Brit Mollenhauer
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-18
Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations

Combination of selection scans and gene network analyses aimed at detecting genomic signatures of natural selection on multiple loci reveal insights into convergent polygenic adaptations evolved by high-altitude Andean and Himalayan human populations

Giulia Ferraretti
Aina Rill
Marco Sazzini
ResearchOpen Access06 Mar 2025
Communications Biology

Volume: 8, P: 1-10
Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Alberto Montesanto
Anna Rita Bonfigli
Giuseppina Rose
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
Isolated populations as treasure troves in genetic epidemiology: the case of the Basques

Paolo Garagnani
Hafid Laayouni
Francesc Calafell
Research06 May 2009
European Journal of Human Genetics

Volume: 17, P: 1490-1494
Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Many mechanistic processes during ageing and age-related diseases cause inflammation. In this Review, the authors discuss the relationship between the immune and metabolic systems during ageing and age-related diseases and the potential use of new biomarkers capable of distinguishing between biological and chronological age in metabolic diseases.

Claudio Franceschi
Paolo Garagnani
Aurelia Santoro
Reviews25 Jul 2018
Nature Reviews Endocrinology

Volume: 14, P: 576-590
Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells

Deborah Ramini
Angelica Giuliani
Fabiola Olivieri
ResearchOpen Access20 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-20
Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

Marco Sazzini
Guido Alberto Gnecchi Ruscone
Donata Luiselli
ResearchOpen Access01 Sept 2016
Scientific Reports

Volume: 6, P: 1-11
Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients

Elisa Zago
Alessandra Dal Molin
Elisa Zago
ResearchOpen Access25 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Luca Baldelli
Chiara Pirazzini
Federica Provini
ResearchOpen Access30 Mar 2023
npj Parkinson's Disease

Volume: 9, P: 1-4
Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Alberto Montesanto
Anna Rita Bonfigli
Giuseppina Rose
Amendments and CorrectionsOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1
Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease

Pilar Gómez-Garre
María Teresa Periñán
Pablo Mir
ResearchOpen Access12 Nov 2022
npj Parkinson's Disease

Volume: 8, P: 1-8
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Gaia Meoni
Leonardo Tenori
Claudio Luchinat
ResearchOpen Access08 Feb 2022
npj Parkinson's Disease

Volume: 8, P: 1-10
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

Luca Baldelli
Sebastian Schade
Federica Provini
ResearchOpen Access07 Sept 2021
npj Parkinson's Disease

Volume: 7, P: 1-10
Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Gianluca Storci
Sabrina De Carolis
Massimiliano Bonafè
Research08 Jan 2019
Cell Death & Differentiation

Volume: 26, P: 1845-1858
Identification of a T cell gene expression clock obtained by exploiting a MZ twin design

Daniel Remondini
Nathan Intrator
Gastone Castellani
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-8

Search

Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset

Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Isolated populations as treasure troves in genetic epidemiology: the case of the Basques

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients

Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder

Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease

Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Identification of a T cell gene expression clock obtained by exploiting a MZ twin design

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