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Showing 1–2 of 2 results
Advanced filters: Author: Parameshwaran Ramanan Clear advanced filters

  • The MuvB protein complex regulates genes that are differentially expressed through the cell cycle, yet its precise molecular function has remained unclear. Here the authors reveal MuvB associates with the nucleosome adjacent to the transcription start site of cell-cycle genes and that the tight positioning of this nucleosome correlates with MuvB-dependent gene repression.

    • Anushweta Asthana
    • Parameshwaran Ramanan
    • Seth M. Rubin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The protein VP35 from Ebola virus contributes to immune evasion by antagonizing interferon signaling pathways. Now the crystal structure of the interferon inhibitory domain of VP35 bound to dsRNA indicates that VP35 sequesters the dsRNA ends, preventing them from being sensed by RIG-I-like receptors and inhibiting immune responses.

    • Daisy W Leung
    • Kathleen C Prins
    • Gaya K Amarasinghe
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 165-172