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Showing 1–4 of 4 results
Advanced filters: Author: Pardeep Heir Clear advanced filters

  • Malignant peripheral nerve sheath tumours are an aggressive form of sarcoma, with limited treatment options. Here, the authors utilise DNA methylation and transcriptomic data to identify two subtypes of tumours with potential therapeutic vulnerabilities.

    • Suganth Suppiah
    • Sheila Mansouri
    • Gelareh Zadeh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.

    • Severa Bunda
    • Pardeep Heir
    • Kenneth Aldape
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Aberrant Ras signalling resulting in downstream Mek/Erk pathway activation is found in many cancers. Here, the authors show that the phosphatase SHP2 dephosphorylates Ras resulting in increased Ras activity, and that increased SHP2 activity is found in glioblastomas.

    • Severa Bunda
    • Kelly Burrell
    • Michael Ohh
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Individuals with Chuvash polycythemia have an increased red blood cell count and are prone to developing blood clots. Although mutations affecting the VHL protein are known to be causative, the underlying molecular mechanisms have been unclear. Ryan C Russell et al. now show that VHL targets the key signaling molecule JAK2 for degradation by forming a complex with the SOCS1 protein. The authors also show that JAK2 inhibition has beneficial effects in a mouse model of this disease, pointing to a new therapeutic strategy.

    • Ryan C Russell
    • Roxana I Sufan
    • Michael Ohh
    Research
    Nature Medicine
    Volume: 17, P: 845-853