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Advanced filters: Author: Parthav Jailwala Clear advanced filters

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.

Urbain Weyemi
Bindu D. Paul
Solomon H. Snyder
ResearchOpen Access18 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Recommendations are given on optimal read coverage and selection of calling algorithm to maximize the reproducibility of cancer mutation detection in whole-genome or whole-exome sequencing.

Wenming Xiao
Luyao Ren
Leming Shi
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1141-1150
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Li Tai Fang
Bin Zhu
Yuanting Zheng
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1151-1160