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Showing 1–3 of 3 results
Advanced filters: Author: Parvinder Hothi Clear advanced filters

  • The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.

    • Javier I. J. Orozco
    • Theo A. Knijnenburg
    • Diego M. Marzese
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • There is a lack of blood biomarkers to diagnose glioblastoma (GBM) patients. This retrospective pilot study aims to determine cell-free microRNAs (cfmiRs) in plasma samples from primary and recurrent GBM patients. Thus, 142 plasma and tissue samples were analyzed using the HTG miRNA whole transcriptome assay (WTA). By combining bioinformatic analysis and receiver operating characteristic curves, we showed that cfmiR-3180-3p and cfmiR-5739 have potential utility in primary and recurrent GBM diagnosis.

    • Matias A. Bustos
    • Negin Rahimzadeh
    • Dave S. B. Hoon
    Research
    Laboratory Investigation
    Volume: 102, P: 711-721