Nature Search

Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4

Pascal Devant
Ying Dong
Jonathan C. Kagan
Amendments and Corrections03 Jan 2024
Nature

Volume: 625, P: E17
Structural insights into cytokine cleavage by inflammatory caspase-4

The human lipopolysaccharide receptor caspase-4 captures its cytokine substrate pro-IL-18 via a mechanism that is distinct from known caspase–substrate interactions, leading to inflammasome-independent IL-18 release from macrophages.

Pascal Devant
Ying Dong
Jonathan C. Kagan
Research22 Nov 2023
Nature

Volume: 624, P: 451-459
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Mutations within subunits of the tRNA splicing endonuclease complex (TSEN) are associated with pontocerebellar hypoplasia (PCH). Here the authors show that tRNA intron excision is catalyzed by tetrameric TSEN assembled from inactive heterodimers, and provide evidence that modulation of TSEN stability may contribute to PCH phenotypes.

Samoil Sekulovski
Pascal Devant
Simon Trowitzsch
ResearchOpen Access28 Sept 2021
Nature Communications

Volume: 12, P: 1-15
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

Gasdermin D Cys191 is S-palmitoylated, and palmitoylation is required for pore formation.

Gang Du
Liam B. Healy
Hao Wu
Research10 Apr 2024
Nature

Volume: 630, P: 437-446
Molecular mechanisms of gasdermin D pore-forming activity

Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D pore-forming activity and its diverse downstream immunological effects.

Pascal Devant
Jonathan C. Kagan
Reviews05 Jun 2023
Nature Immunology

Volume: 24, P: 1064-1075

Quick links

Search

Filter By:

Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4

Structural insights into cytokine cleavage by inflammatory caspase-4

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

Molecular mechanisms of gasdermin D pore-forming activity

Search

Quick links