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Showing 1–2 of 2 results
Advanced filters: Author: Pascal Guntern Clear advanced filters

  • Brigger et al. show that adipose tissue eosinophil dysfunction with age underpins physiological features of ageing, including global inflammation, loss of physical fitness and myeloid skewing. Eosinophils transferred from young to aged mice reversed these features and improved immunological fitness in old age, in part via IL-4.

    • Daniel Brigger
    • Carsten Riether
    • Alexander Eggel
    Research
    Nature Metabolism
    Volume: 2, P: 688-702

  • Immunoglobulin E (IgE) plays a central role in allergic responses, yet therapeutic targeting of IgE with antibodies such as omalizumab is met with various limitations. Here the authors characterize the molecular properties and crystal structure of a new anti-IgE antibody, ligelizumab, for mechanistic insights related to its enhanced suppression activity.

    • Pascal Gasser
    • Svetlana S. Tarchevskaya
    • Alexander Eggel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14