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Showing 1–2 of 2 results
Advanced filters: Author: Pascal Preker Clear advanced filters

  • Most mammalian promoters are inherently bidirectional, but transcription only elongates productively in one direction. Data presented in this paper demonstrate that at least part of the answer lies in the asymmetric distribution of polyadenylation-site sequences around human gene promoters causing termination of upstream antisense transcription.

    • Evgenia Ntini
    • Aino I Järvelin
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 923-928

  • The nature of small RNA species derived from gene termini and intron-exon junctions is now further examined. By sequencing transcripts between 12 and 100 nucleotides derived from cells depleted for RNA decay factors as well as those associated with Argonaute proteins, insights into how these RNAs are produced is provided. Moreover, new small RNAs are identified.

    • Eivind Valen
    • Pascal Preker
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1075-1082