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Showing 1–2 of 2 results
Advanced filters: Author: Patrice Mascalchi Clear advanced filters

  • Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25.

    • Lovorka Stojic
    • Aaron T. L. Lun
    • Fanni Gergely
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-21

  • Tumours with homologous recombination (HR) defects become sensitive to PARPi. Here, the authors show that androgen receptor (AR) regulates HR and AR inhibition activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective treatment of high risk prostate cancer.

    • Mohammad Asim
    • Firas Tarish
    • Thomas Helleday
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10