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Showing 1–5 of 5 results
Advanced filters: Author: Patricia Tebabi Clear advanced filters

  • The human serum protein apolipoprotein L1 (APOL1) is taken up by trypanosomes where it triggers cell death, forming pores in endolysosomal membranes. Vanwalleghem et al.show that APOL1 triggers both lysosomal and mitochondrial membrane permeabilization, and that the latter is responsible for trypanolysis.

    • Gilles Vanwalleghem
    • Frédéric Fontaine
    • Etienne Pays
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • This study shows that Trypanosoma brucei gambiense resists trypanolytic factors (TLFs) in a multifactorial manner, relying on a hydrophobic β-sheet of the TgsGP glycoprotein, which prevents APOL1 toxicity and induces membrane stiffening, as well as a reduction in sensitivity to APOL1 requiring cysteine protease activity and TLF-1 receptor inactivation owing to a single amino acid substitution.

    • Pierrick Uzureau
    • Sophie Uzureau
    • Etienne Pays
    Research
    Nature
    Volume: 501, P: 430-434

  • Recombinant proteins based on APOL1 and APOL3 can kill pathogenic Trypanosoma brucei subspecies, including a variant (rPpMUT) that is effective against T.b. gambiense infection in mice, suggesting that it may serve as a therapy against sleeping sickness.

    • Frédéric Fontaine
    • Laurence Lecordier
    • Etienne Pays
    Research
    Nature Microbiology
    Volume: 2, P: 1500-1506