Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Patrick D. Bosshart Clear advanced filters

  • The transport of L-lactate across plasma membranes is catalyzed by proton-driven monocarboxylate transporters (MCTs) of the SLC16 solute carrier family. Here, the authors present the crystal structures of a bacterial SLC16 homologue with the bound substrate L-lactate and ligand thiosalicylate both in an outward-open conformation and discuss the L-lactate transport mechanism.

    • Patrick D. Bosshart
    • David Kalbermatter
    • Dimitrios Fotiadis
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexes are presented unveiling interactions at the atomic level.

    • Patrick D. Bosshart
    • David Kalbermatter
    • Dimitrios Fotiadis
    ResearchOpen Access
    Communications Chemistry
    Volume: 4, P: 1-9

  • Johannes Thoma et al. overexpress outer membrane proteins (Omps) in Escherichia coli and collect the expelled outer membrane vesicles (OMVs) to study Omp assembly, folding and structure. They find that Omps in OMVs show different unfolding pathways compared to Omps reconstituted in artificial lipid membranes.

    • Johannes Thoma
    • Selen Manioglu
    • Daniel J. Müller
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-9