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Showing 1–11 of 11 results
Advanced filters: Author: Patrick J. Michaels Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Group-IV color centers in diamond show promise for spin-photon interfaces, but precise positioning and activation are challenging. Here the authors combine site-controlled ion implantation with laser annealing and in-situ photoluminescence monitoring to create and tune individual tin vacancy centers in diamond.

    • Xingrui Cheng
    • Andreas Thurn
    • Dorian A. Gangloff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impairments in social and communication skills. Accumulating evidence suggests a genetic component to ASDs, and here a two-stage, genome-wide approach is used to identify candidate genomic loci enriched in ASD cases. The majority of these loci are found to be involved in neuronal adhesion and ubiquitin degradation, suggesting novel susceptibility mechanisms.

    • Joseph T. Glessner
    • Kai Wang
    • Hakon Hakonarson
    Research
    Nature
    Volume: 459, P: 569-573

  • The expression of each of the roughly 22,000 genes of the mouse genome has been mapped, at cellular resolution, across all major structures of the mouse brain, revealing that 80% of all genes appear to be expressed in the brain.

    • Ed S. Lein
    • Michael J. Hawrylycz
    • Allan R. Jones
    Research
    Nature
    Volume: 445, P: 168-176

  • The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

    • Tim H. H. Coorens
    • Ji Won Oh
    • Yuqing Wang
    Reviews
    Nature
    Volume: 643, P: 47-59

  • Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisation and gain mechanistic insight into their modes of action.

    • Roxine Staats
    • Thomas C. T. Michaels
    • Michele Vendruscolo
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-9

  • Acute kidney injury (AKI) and chronic kidney disease are increasingly recognized as interconnected entities and the term acute kidney disease (AKD) has been proposed to define ongoing pathophysiologic processes following an episode of AKI. In this Consensus statement, the Acute Disease Quality Initiative 16 Workgroup propose definitions and staging criteria for AKD, and strategies for the management of affected patients. They also make recommendations for areas of future research with the aims of improving understanding of the underlying processes and improving outcomes.

    • Lakhmir S. Chawla
    • Rinaldo Bellomo
    • John A. Kellum
    ReviewsOpen Access
    Nature Reviews Nephrology
    Volume: 13, P: 241-257