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Showing 1–3 of 3 results

Advanced filters: Author: Patrick L. Wintrode Clear advanced filters

Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation

AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel specificities and functions.

Erik H. Klontz
Chao Li
Eric J. Sundberg
ResearchOpen Access04 Dec 2020
Nature Communications

Volume: 11, P: 1-14
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Members of the hydrogen deuterium exchange mass spectrometry (HDX-MS) community provide their ‘best practices’ recommendations for HDX-MS data collection, analysis and reporting.

Glenn R. Masson
John E. Burke
Kasper D. Rand
ReviewsOpen Access27 Jun 2019
Nature Methods

Volume: 16, P: 595-602
Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy

Yuko Tsutsui
Daniel Deredge
Franklin A. Hays
ResearchOpen Access02 Aug 2016
Scientific Reports

Volume: 6, P: 1-11