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Genomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi

Malawi experienced a large cholera outbreak in 2022-2023 that was associated with high morbidity and mortality and distributed across all 29 districts of the country. This study describes the epidemiological and genomic features of the outbreak and attempts to understand the reasons for its severity.

Chrispin Chaguza
Innocent Chibwe
Khuzwayo C. Jere
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales

In this work, authors probe the molecular mechanism of re-emerging CHL susceptibility in Malawian Enterobacterales isolates, where they identify a stable truncation of resistance genes by insertion sequences.

Fabrice E. Graf
Richard N. Goodman
Nicholas A. Feasey
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Time to define One Health approaches to tackling antimicrobial resistance

Antimicrobial resistance is a One Health problem that impacts humans, animals, and the environment. In this Comment, the authors discuss evidence for antimicrobial resistance transmission to humans, highlighting contrasting pictures between high- and low/middle-income settings.

Patrick Musicha
Tracy Morse
Nicholas A. Feasey
Comments & OpinionOpen Access10 Oct 2024
Nature Communications

Volume: 15, P: 1-3
High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach

Pearse et al. use whole genome sequencing to describe the antigenic and overall diversity of 169 Escherichia coli isolates causing invasive infections in neonates in a single hospital in Malawi. High levels of O-antigen diversity are found, highlighting the difficulty of developing a vaccine for this patient population.

Oliver Pearse
Allan Zuza
Eva Heinz
ResearchOpen Access18 Jul 2025
Communications Medicine

Volume: 5, P: 1-13
Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Modelling combined with epidemiological and genomic data analysis from a hospital in Spain reveals frequent transmission of high-risk pOXA-48-carrying enterobacteria clones between patients and horizontal transfer of pOXA-48 plasmid within patients.

Ricardo León-Sampedro
Javier DelaFuente
Álvaro San Millán
Research29 Mar 2021
Nature Microbiology

Volume: 6, P: 606-616
Genomic epidemiology on the move

This Genome Watch article explores how portable sequencing technology is re-shaping the field of genomic epidemiology.

Catherine N. Wilson
Patrick Musicha
Mathew A. Beale
News19 Dec 2022
Nature Reviews Microbiology

Volume: 21, P: 69
Updated fine-scale location data for Blantyre district collected using a low-cost approach

Chifuniro Baluwa
Patrick Ken Kalonde
James Chirombo
ResearchOpen Access22 Jul 2025
Scientific Data

Volume: 12, P: 1-12

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Genomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales

Time to define One Health approaches to tackling antimicrobial resistance

High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Genomic epidemiology on the move

Updated fine-scale location data for Blantyre district collected using a low-cost approach

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Genomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales

Time to define One Health approaches to tackling antimicrobial resistance

High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach

Pervasive transmission of a carbapenem resistance plasmid in the gut microbiota of hospitalized patients

Genomic epidemiology on the move

Updated fine-scale location data for Blantyre district collected using a low-cost approach

Search

Quick links