The fluorine isotope 18F is a PET nuclide used for imaging studies, but the incorporation of [18F]HF into 2,2-difluorovinyl groups to generate radiotracers and labeling reagents has only been achieved in low yields. Here, using a combination of Et3SiH and TEMPO in the absence of oxidizing agents is shown to afford a higher yield, better product quality, and controllable selectivity between the formation of a S–F or C–F bond.
- Mudasir Maqbool
- Jimmy Erik Jakobsson
- Patrick Johannes Riss
