Drugs that induce redifferentiation of cancer cells are efficient only in some subtypes of AML. The authors show that sensitivity to pro-differentiation drugs such as ATRA can be induced by co-treatment with epigenetic drugs. An inhibitor of histone demethylase, LSD1, safely used as an antidepressant in humans, reprograms AML cells and makes them sensitive to the effects of ATRA in vitro and in vivo, suggesting that epigenetic interventions can increase response to cancer treatments.
- Tino Schenk
- Weihsu Claire Chen
- Arthur Zelent
