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Showing 1–21 of 21 results
Advanced filters: Author: Patrick Y.S Lam Clear advanced filters

  • Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.

    • Dhakshayini Morgan
    • Biyan Zhang
    • Vinay Tergaonkar
    Research
    Nature Immunology
    Volume: 26, P: 1553-1566

  • Genome-wide meta-analysis with individuals of East Asian or European ancestry identifies 176 loci associated with schizophrenia. Despite consistent genetic effects across populations, polygenic risk models trained in one population have reduced performance in the other population.

    • Max Lam
    • Chia-Yen Chen
    • Hailiang Huang
    Research
    Nature Genetics
    Volume: 51, P: 1670-1678

  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712

  • A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

    • Vassily Trubetskoy
    • Antonio F. Pardiñas
    • Jim van Os
    Research
    Nature
    Volume: 604, P: 502-508

  • A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

    • Aniket Mishra
    • Rainer Malik
    • Stephanie Debette
    ResearchOpen Access
    Nature
    Volume: 611, P: 115-123

  • A draft map of the human proteome is presented here, accounting for over 80% of the annotated protein-coding genes in humans; some novel protein-coding regions, including translated pseudogenes, non-coding RNAs and upstream open reading frames, are identified.

    • Min-Sik Kim
    • Sneha M. Pinto
    • Akhilesh Pandey
    Research
    Nature
    Volume: 509, P: 575-581

  • Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic markers.

    • Matthew T. Patrick
    • Philip E. Stuart
    • Lam C. Tsoi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

    • James H. Leebens-Mack
    • Michael S. Barker
    • Gane Ka-Shu Wong
    ResearchOpen Access
    Nature
    Volume: 574, P: 679-685

  • Genomic analyses in large cohorts of patients with cancer identify a new measure of tumor mutational burden, based on genomic regions that are unlikely to undergo loss, that is associated with therapeutic response to immunotherapy.

    • Noushin Niknafs
    • Archana Balan
    • Valsamo Anagnostou
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 440-449

  • Polygenic risk scores predict the likelihood that an individual will develop a certain cancer, however these are often specific for a given population. Here, the authors show that a risk score developed to assess the risk of breast cancer in European women can also predict risk in Asian populations.

    • Weang-Kee Ho
    • Min-Min Tan
    • Antonis C. Antoniou
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.

    • Xiaohong Ruby Xu
    • Yiming Wang
    • Heyu Ni
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405

  • Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

    • Kyriaki Michailidou
    • Sara Lindström
    • Douglas F. Easton
    Research
    Nature
    Volume: 551, P: 92-94