Kavšek et al. reveal in this C. elegans study that the LIN-39 and DAF-16 transcription factors cooperate to regulate enhancer activity in VC neurons and ensure proper neuron maturation. This in turn is required for longevity under reduced IIS conditions, linking chromatin dynamics to lifespan extension.
- Alan Kavšek
- Jérôme Salignon
- Christian G. Riedel
