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Showing 1–7 of 7 results
Advanced filters: Author: Paul B. Romesser Clear advanced filters

  • The role of B-cell-receptor (BCR) signalling in human B cell lymphomas has been a long-standing question, with genetic and functional evidence for its oncogenic role in human lymphomas lacking. Here, a form of 'chronic active' BCR signalling that is required for cell survival in the activated B-cell-like subtype of diffuse large B-cell lymphoma is described and analysed, with potential implications for future therapeutic strategies.

    • R. Eric Davis
    • Vu N. Ngo
    • Louis M. Staudt
    Research
    Nature
    Volume: 463, P: 88-92

  • This study finds frequent mutations in MYD88 in the activated B-cell-like subtype of diffuse large B-cell lymphoma and, with lower frequency, in mucosa-associated lymphoid tissue lymphomas. MYD88 mediates signalling by Toll-like receptors, and the mutations, most of which affect the same amino acid, are shown to activate the pathway and promote cancer cell survival.

    • Vu N. Ngo
    • Ryan M. Young
    • Louis M. Staudt
    Research
    Nature
    Volume: 470, P: 115-119

  • In this article, the authors discuss the use of total neoadjuvant therapy for locally advanced rectal cancer. They highlight ongoing trials and discuss future treatment options, including the potential use of multi-omics and artificial intelligence to facilitate treatment selection and prediction of response.

    • Yoshinori Kagawa
    • J. Joshua Smith
    • Takayuki Yoshino
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 21, P: 444-455