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Showing 1–4 of 4 results
Advanced filters: Author: Paul Colussi Clear advanced filters

  • Current methods for production of monoclonal antibodies often require refolding steps or secretion across biological membranes. Here, Robinson et al. describe engineered E. colistrains for efficient production of functional immunoglobulin G antibodies in the bacterial cytoplasm.

    • Michael-Paul Robinson
    • Na Ke
    • Mehmet Berkmen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

    • Timothy M. Colussi
    • David A. Costantino
    • Jeffrey S. Kieft
    Research
    Nature
    Volume: 519, P: 110-113

  • Ion channels are attractive therapeutic targets for a wide range of diseases, but achieving sufficient selectivity with small-molecule drugs can be challenging. In this Review, Wulff and colleagues discuss strategies to selectively modulate ion channel function using biologics — namely, antibodies and venom-derived peptides — highlighting opportunities, hurdles and future directions for the field.

    • Heike Wulff
    • Palle Christophersen
    • Vladimir Yarov-Yarovoy
    Reviews
    Nature Reviews Drug Discovery
    Volume: 18, P: 339-357